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Details on Person UniProt:P00387-1 CYB5R3
| Class:Id | ReferenceIsoform:402221 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-301 added on Fri February 6 2015;chain:27-301 added on Fri February 6 2015;chain:27-301 for 402221 removed on Fri November 4 2022;initiator methionine:1 for 402221 removed on Fri Nov 03 2023;initiator methionine: for 402221 added on Fri Nov 03 2023;initiator methionine: for 402221 removed on Fri Aug 15 2025;initiator methionine:1 for 402221 added on Fri Aug 15 2025 |
| _displayName | UniProt:P00387-1 CYB5R3 |
| _timestamp | 2025-08-15 21:47:00 |
| chain | initiator methionine:1 chain:2-301 |
| checksum | FDCDCDC4EC3570B4 |
| comment | FUNCTION Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor.CATALYTIC ACTIVITY 2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)CATALYTIC ACTIVITY 2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)COFACTOR kcat is 896 sec(-1).SUBUNIT Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MTARC2 (By similarity). Interacts with MTLN; the interaction is required to maintain cellular lipid composition and leads to stimulation of mitochondrial respiratory complex I activity (By similarity).INTERACTION Expressed at late stages of erythroid maturation.POLYMORPHISM Ser-117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It was not found in Caucasians, Asians, Indo-Aryans, or Arabs. There seems to be no effect on the enzyme activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="28"NADH-cytochrome b5 reductase 3 shortName: B5R shortName: Cytochrome b5 reductase ecNumber evidence="5 7 10 12 13 19 21"1.6.2.2 alternativeName: fullName evidence="27"Diaphorase-1 |
| geneName | CYB5R3 DIA1 |
| identifier | P00387 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative promoter usage Alternative splicing Cholesterol biosynthesis Cholesterol metabolism Cytoplasm Direct protein sequencing Disease variant Endoplasmic reticulum FAD Flavoprotein Lipid biosynthesis Lipid metabolism Lipoprotein Membrane Mitochondrion Mitochondrion outer membrane Myristate NAD Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CYB5R3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003089] ENSEMBL:ENSG00000100243 CYB5R3 [Homo sapiens] |
| secondaryIdentifier | NB5R3_HUMAN B1AHF2 B7Z7L3 O75675 Q8TDL8 Q8WTS8 Q9UEN4 Q9UEN5 Q9UL55 Q9UL56 |
| sequenceLength | 301 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | P00387-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P00387-1 CYB5R3 (402221)
