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Details on Person UniProt:O95402 MED26
| Class:Id | ReferenceGeneProduct:402142 |
|---|---|
| _chainChangeLog | chain:1-600 added on Fri February 6 2015 |
| _displayName | UniProt:O95402 MED26 |
| _timestamp | 2024-11-03 19:37:30 |
| chain | chain:1-600 |
| checksum | 4BEA264A3EB5A407 |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB (when not methylated) (PubMed:20111005).INTERACTION Belongs to the Mediator complex subunit 26 family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 26 alternativeName: Activator-recruited cofactor 70 kDa component shortName: ARC70 alternativeName: Cofactor required for Sp1 transcriptional activation subunit 7 shortName: CRSP complex subunit 7 alternativeName: Mediator complex subunit 26 alternativeName: Transcriptional coactivator CRSP70 |
| geneName | MED26 ARC70 CRSP7 |
| identifier | O95402 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MED26 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003063] ENSEMBL:ENSG00000105085 MED26 [Homo sapiens] |
| secondaryIdentifier | MED26_HUMAN A1A4S3 Q0VGB6 |
| sequenceLength | 600 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:212199] UniProt:O95402-2 MED26 [Homo sapiens] [ReferenceIsoform:212214] UniProt:O95402-1 MED26 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:556783] MED26 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95402 MED26 (402142)
