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Details on Person UniProt:O60683-1 PEX10
| Class:Id | ReferenceIsoform:401718 |
|---|---|
| _chainChangeLog | chain:1-326 added on Sat February 7 2015 |
| _displayName | UniProt:O60683-1 PEX10 |
| _timestamp | 2024-11-03 19:57:56 |
| chain | chain:1-326 |
| checksum | 9CF2CE5E4C797799 |
| comment | FUNCTION E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (PubMed:24662292). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX10 also regulates PEX5 recycling by acting as a E3 ubiquitin-protein ligase (PubMed:24662292). When PEX5 recycling is compromised, PEX10 catalyzes polyubiquitination of PEX5 during its passage through the retrotranslocation channel, leading to its degradation (By similarity).CATALYTIC ACTIVITY S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ACTIVITY REGULATION The E3 ubiquitin-protein ligase activity is stimulated by PEX12.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12 (PubMed:24662292). Interacts with PEX19 (PubMed:10704444, PubMed:11390669).SUBCELLULAR LOCATION The three subunits of the retrotranslocation channel (PEX2, PEX10 and PEX12) coassemble in the membrane into a channel with an open 10 Angstrom pore (By similarity). The RING-type zinc-fingers that catalyze PEX5 receptor ubiquitination are positioned above the pore on the cytosolic side of the complex (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the pex2/pex10/pex12 family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: fullName evidence="20"Peroxisome biogenesis factor 10 ecNumber evidence="10"2.3.2.27 alternativeName: fullName evidence="20"Peroxin-10 alternativeName: Peroxisomal biogenesis factor 10 alternativeName: Peroxisome assembly protein 10 alternativeName: RING finger protein 69 |
| geneName | PEX10 RNF69 |
| identifier | O60683 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Disease variant Membrane Metal-binding Peroxisome Peroxisome biogenesis Peroxisome biogenesis disorder Protein transport Proteomics identification Reference proteome Transferase Transmembrane Transmembrane helix Transport Ubl conjugation pathway Zellweger syndrome Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PEX10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996786] ENSEMBL:ENSG00000157911 PEX10 [Homo sapiens] |
| secondaryIdentifier | PEX10_HUMAN B3KWD8 Q5T095 Q9BW90 |
| sequenceLength | 326 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O60683-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O60683-1 PEX10 (401718)
