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Details on Person UniProt:O43157 PLXNB1
| Class:Id | ReferenceGeneProduct:401487 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;chain:20-2135 added on Fri February 6 2015 |
| _displayName | UniProt:O43157 PLXNB1 |
| _timestamp | 2024-11-03 20:11:32 |
| chain | signal peptide:1-19 chain:20-2135 |
| checksum | 12A81B68AF1D340F |
| comment | FUNCTION Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496).SUBUNIT Monomer, and heterodimer with PLXNB2 after proteolytic processing (PubMed:12533544, PubMed:17916560, PubMed:18275816, PubMed:18411422, PubMed:19843518, PubMed:20877282, PubMed:21912513). Binds RAC1 that has been activated by GTP binding (PubMed:11035813, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interaction with SEMA4D promotes binding of cytoplasmic ligands (PubMed:10520995, PubMed:12198496, PubMed:19843518). Interacts with PLXNA1 (By similarity). Interacts with ARHGEF11 and ARHGEF12 (PubMed:12196628). Interacts with ERBB2 (PubMed:15210733). Interacts with MET (PubMed:12198496, PubMed:15184888). Interacts with MST1R (PubMed:15184888). Interacts with RRAS (PubMed:19843518). Interacts with RHOD (PubMed:17916560). Interacts with RND1 (PubMed:12730235, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interacts with NRP1 and NRP2 (PubMed:10520995).INTERACTION Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver.PTM Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding.PTM Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding.SIMILARITY Belongs to the plexin family.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Plexin-B1 alternativeName: Semaphorin receptor SEP |
| geneName | PLXNB1 KIAA0407 PLXN5 SEP |
| identifier | O43157 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Coiled coil Disulfide bond Glycoprotein Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PLXNB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9004321] ENSEMBL:ENSG00000164050 PLXNB1 [Homo sapiens] |
| secondaryIdentifier | PLXB1_HUMAN A6H8Y2 Q6NY20 Q9UIV7 Q9UJ92 Q9UJ93 |
| sequenceLength | 2135 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152655] UniProt:O43157-1 PLXNB1 [Homo sapiens] [ReferenceIsoform:152656] UniProt:O43157-2 PLXNB1 [Homo sapiens] [ReferenceIsoform:152657] UniProt:O43157-3 PLXNB1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:419609] p-Y-PLXNB1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3008951] PLXNB1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O43157 PLXNB1 (401487)
