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Details on Person UniProt:O15315 RAD51B
| Class:Id | ReferenceGeneProduct:401330 |
|---|---|
| _chainChangeLog | chain:1-384 added on Fri February 6 2015 |
| _displayName | UniProt:O15315 RAD51B |
| _timestamp | 2024-11-03 20:20:58 |
| chain | chain:1-384 |
| checksum | DB0B9AE82F44A52B |
| comment | FUNCTION Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.SUBUNIT Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354). The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51 (PubMed:11744692, PubMed:11751635, PubMed:11751636, PubMed:11842112, PubMed:11842113, PubMed:12427746, PubMed:14704354). Interacts with SWSAP1; involved in homologous recombination repair (PubMed:21965664). Interacts with HELQ (PubMed:24005041).INTERACTION Expressed in a wide range of tissues.PTM Phosphorylated on tyrosine residues by BCR-ABL.DISEASE A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1.DISEASE A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2.SIMILARITY Belongs to the RecA family. RAD51 subfamily.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: DNA repair protein RAD51 homolog 2 shortName: R51H2 alternativeName: RAD51 homolog B shortName: Rad51B alternativeName: RAD51-like protein 1 |
| geneName | RAD51B RAD51L1 REC2 |
| identifier | O15315 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Chromosomal rearrangement DNA damage DNA recombination DNA repair DNA-binding Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RAD51B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996820] ENSEMBL:ENSG00000182185 RAD51B [Homo sapiens] |
| secondaryIdentifier | RA51B_HUMAN O60914 O75210 Q3Y4F8 Q6FHX8 Q86SY3 Q86SY4 Q86TR0 Q86U92 Q86U93 Q86U94 Q8N6H4 Q9UPL5 |
| sequenceLength | 384 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:152706] UniProt:O15315-2 RAD51B [Homo sapiens] [ReferenceIsoform:216977] UniProt:O15315-1 RAD51B [Homo sapiens] [ReferenceIsoform:216987] UniProt:O15315-3 RAD51B [Homo sapiens] [ReferenceIsoform:217100] UniProt:O15315-4 RAD51B [Homo sapiens] [ReferenceIsoform:217155] UniProt:O15315-5 RAD51B [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:983271] RAD51B [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O15315 RAD51B (401330)
