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Details on Person UniProt:O14776-1 TCERG1
| Class:Id | ReferenceIsoform:401259 |
|---|---|
| _chainChangeLog | chain:1-1098 added on Fri February 6 2015 |
| _displayName | UniProt:O14776-1 TCERG1 |
| _timestamp | 2024-11-03 20:21:49 |
| chain | chain:1-1098 |
| checksum | 5F0A0C3A07EBF00F |
| comment | FUNCTION Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.SUBUNIT Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1.INTERACTION Detected in brain neurons.INDUCTION Up-regulated in brain tissue from patients with Huntington disease.DOMAIN The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5).DOMAIN The WW domains bind Pro-rich domains.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Transcription elongation regulator 1 alternativeName: TATA box-binding protein-associated factor 2S alternativeName: Transcription factor CA150 |
| geneName | TCERG1 CA150 TAF2S |
| identifier | O14776 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Coiled coil Direct protein sequencing Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | TCERG1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996312] ENSEMBL:ENSG00000113649 TCERG1 [Homo sapiens] |
| secondaryIdentifier | TCRG1_HUMAN Q2NKN2 Q59EA1 |
| sequenceLength | 1098 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O14776-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O14776-1 TCERG1 (401259)
