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Details on Person UniProt:O00470-1 MEIS1
| Class:Id | ReferenceIsoform:401121 |
|---|---|
| _chainChangeLog | chain:1-390 added on Fri February 6 2015 |
| _displayName | UniProt:O00470-1 MEIS1 |
| _timestamp | 2024-11-03 19:37:30 |
| chain | chain:1-390 |
| checksum | 3B6A0ACCF0C39121 |
| comment | FUNCTION Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.SUBUNIT Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner. Heterodimer with DLX3 (PubMed:26550823). Heterodimer with HOXB13 (PubMed:28473536).INTERACTION Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.DISEASE Disease susceptibility may be associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the TALE/MEIS homeobox family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Homeobox protein Meis1 |
| geneName | MEIS1 |
| identifier | O00470 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Proteomics identification Reference proteome Transcription |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MEIS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996098] ENSEMBL:ENSG00000143995 MEIS1 [Homo sapiens] |
| secondaryIdentifier | MEIS1_HUMAN A8MV50 |
| sequenceLength | 390 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O00470-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00470-1 MEIS1 (401121)
