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Details on Person UniProt:O00222-1 GRM8
| Class:Id | ReferenceIsoform:401094 |
|---|---|
| _chainChangeLog | signal peptide:1-33 added on Fri February 6 2015;chain:34-908 added on Fri February 6 2015 |
| _displayName | UniProt:O00222-1 GRM8 |
| _timestamp | 2024-11-03 19:56:33 |
| chain | signal peptide:1-33 chain:34-908 |
| checksum | 95C2D5883DAF6FDE |
| comment | FUNCTION G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.SUBUNIT Interacts with PICK1.SUBCELLULAR LOCATION Belongs to the G-protein coupled receptor 3 family. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Metabotropic glutamate receptor 8 shortName: mGluR8 |
| geneName | GRM8 GPRC1H MGLUR8 |
| identifier | O00222 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Isopeptide bond Membrane Proteomics identification Receptor Reference proteome Sensory transduction Signal Transducer Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GRM8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996604] ENSEMBL:ENSG00000179603 GRM8 [Homo sapiens] |
| secondaryIdentifier | GRM8_HUMAN A4D0Y3 B0FZ74 B0M0L0 O15493 O95945 O95946 Q3MIV9 Q52M02 Q6J165 |
| sequenceLength | 908 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O00222-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00222-1 GRM8 (401094)
