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Details on Person UniProt:A9YTQ3-1 AHRR
| Class:Id | ReferenceIsoform:401054 |
|---|---|
| _chainChangeLog | chain:1-701 added on Sat February 7 2015;chain:1-701 for 401054 removed on Fri Feb 20 2026;chain:1-697 for 401054 added on Fri Feb 20 2026 |
| _displayName | UniProt:A9YTQ3-1 AHRR |
| _timestamp | 2026-05-15 20:10:20 |
| chain | chain:1-697 |
| checksum | E0A659DFEC032166 |
| comment | FUNCTION Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with AHR for heterodimer formation with ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of a variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.FUNCTION Represses AHR transcription activity (PubMed:19380484). Also represses transcription mediated by HIF1A and EPAS1/HIF2A but does not repress NR1I2/PXR or ESR1 transcriptional activities (PubMed:19380484).FUNCTION Does not repress AHR transcription activity.SUBUNIT Heterodimer with ARNT; formation of the heterodimer results in repression of the transcription activity of AHR (PubMed:28904176). Interacts with ANKRA2, HDAC4 and HDAC5 (By similarity).SUBUNIT Interacts with ARNT.SUBUNIT Does not interact with ARNT.SUBCELLULAR LOCATION Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.ALTERNATIVE PRODUCTS Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Down-regulated in malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.TISSUE SPECIFICITY Predominant form which is widely expressed in multiple adult and fetal tissues.TISSUE SPECIFICITY Minor form which is expressed at low levels.INDUCTION By 3-methylcholanthrene (3-MC) in MNCs from adults. By the heterodimer AHR/ARNT.POLYMORPHISM The Ala-189 allele may be a susceptibility factor for dioxin-related male infertility. Homozygosity for Ala-189 is observed in azoospermic individuals at higher frequency than in normozoospermic individuals (PubMed:15474075, PubMed:17559847). Might also be associated with susceptibility to and severity of endometriosis.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 |
| description | recommendedName: Aryl hydrocarbon receptor repressor shortName: AhR repressor shortName: AhRR alternativeName: Class E basic helix-loop-helix protein 77 shortName: bHLHe77 |
| geneName | AHRR BHLHE77 KIAA1234 |
| identifier | A9YTQ3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm DNA-binding Isopeptide bond Nucleus Proteomics identification Reference proteome Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 [InstanceEdit:9989145] Weiser, Joel, 2026-05-15 |
| name | AHRR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9657915] ENSEMBL:ENSG00000286169 AHRR [Homo sapiens] |
| secondaryIdentifier | AHRR_HUMAN A0A7I2PK40 A7MBN5 D6RAZ1 Q9HAZ3 Q9ULI6 |
| sequenceLength | 697 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | A9YTQ3-1 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A9YTQ3-1 AHRR (401054)
