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Details on Person The cytoplasmic tails of plexins have two domains, C1 and C2...

Class:Id	Summation:400680
_displayName	The cytoplasmic tails of plexins have two domains, C1 and C2...
_timestamp	2009-05-20 18:44:40
created	[InstanceEdit:400684] Garapati, P V, 2009-03-24 17:46:37
literatureReference	[LiteratureReference:400683] The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding
modified	[InstanceEdit:400690] Garapati, P V, 2009-03-24 17:47:16 [InstanceEdit:421074] Garapati, P V, 2009-05-15 17:03:45 [InstanceEdit:421778] D'Eustachio, P, 2009-05-20 18:44:38
text	The cytoplasmic tails of plexins have two domains, C1 and C2, which are highly conserved and act as GAP for small GTPases like Rac1. Active Rac1 binds directly to a binding domain of Plexin-B1 in the linker region between C1 and C2. The functional consequence of the plexin-B1/Rac interaction is not understood but this binding might sequester Rac1 away from p21-activated kinase (PAK). Plexin-B1 can compete with PAK for binding to active Rac and this competition results in the ability of plexin-B1 to inhibit Rac-induced PAK activation.
(summation)	[Reaction:400682] Active Rac1 interacts with Plexin-B1:Sema4D [Homo sapiens]
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