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Details on Person When a ligand activates a G protein-coupled receptor, it ind...
| Class:Id | Summation:400669 |
|---|---|
| _displayName | When a ligand activates a G protein-coupled receptor, it ind... |
| _timestamp | 2017-04-10 11:16:59 |
| created | [InstanceEdit:400670] Jupe, S, 2009-03-24 17:44:19 |
| literatureReference | [LiteratureReference:374843] Mechanism of GTP hydrolysis by G-protein alpha subunits |
| modified | [InstanceEdit:434704] Jupe, S, 2009-09-02 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:8982644] Varusai, Thawfeek, 2017-03-21 [InstanceEdit:8984615] Duenas, Corina, 2017-04-10 |
| text | When a ligand activates a G protein-coupled receptor, it induces a conformational change in the receptor (a change in shape) that allows the receptor to function as a guanine nucleotide exchange factor (GEF), stimulating the exchange of GDP for GTP on the G alpha subunit. In the traditional view of heterotrimeric protein activation, this exchange triggers the dissociation of the now active G alpha subunit from the beta:gamma dimer, initiating downstream signalling events. The G alpha subunit has intrinsic GTPase activity and will eventually hydrolyze the attached GTP to GDP, allowing reassociation with G beta:gamma. Additional GTPase-activating proteins (GAPs) stimulate the GTPase activity of G alpha, leading to more rapid termination of the transduced signal. In some cases the downstream effector may have GAP activity, helping to deactivate the pathway. This is the case for phospholipase C beta, which possesses GAP activity within its C-terminal region (Kleuss et al. 1994). |
| (summation) | [Reaction:164381] G alpha (s) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392133] G alpha (z) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392212] G alpha (i) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:421896] G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP [Rattus norvegicus] |
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