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Details on Person The activation of adenylyl (adenylate) cyclase (AC) results ...
| Class:Id | Summation:400657 |
|---|---|
| _displayName | The activation of adenylyl (adenylate) cyclase (AC) results ... |
| _timestamp | 2019-01-11 22:19:15 |
| created | [InstanceEdit:400658] Jupe, S, 2009-03-24 17:18:09 |
| literatureReference | [LiteratureReference:374088] Isoforms of mammalian adenylyl cyclase: multiplicities of signaling |
| modified | [InstanceEdit:419685] Jupe, S, 2009-05-05 16:43:12 [InstanceEdit:425333] Jupe, S, 2009-06-03 [InstanceEdit:9634617] Rothfels, Karen, 2019-01-11 |
| text | The activation of adenylyl (adenylate) cyclase (AC) results in the production of adenosine-3',5'-monophosphate i.e. cyclic AMP. Humans have 9 genes encoding membrane-associated AC and one encoding a soluble AC. Two of the classes of heterotrimeric G-proteins are named according to their effect on AC; G(s) stimulates all membrane-bound ACs (the s in G(s) denotes AC stimulatory); the G(i) class inhibits some AC isoforms, particularly 5 and 6. Beta-gamma subunits of heterotrimeric G-proteins can also regulate AC. Ca2+/Calmodulin activates some AC isoforms (1, 8 and 3) but is inhibitory to others (5 and 6). |
| (summation) | [Reaction:392129] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Homo sapiens] [Reaction:421879] Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate [Canis familiaris] |
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