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Details on Person PIAS4 SUMOylates Smad3 with SUMO1

Class:Id	Reaction:4006035
_displayName	PIAS4 SUMOylates Smad3 with SUMO1
_timestamp	2022-01-19 16:42:47
authored	[InstanceEdit:3968435] May, B, 2013-07-23
catalystActivity	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643693] SUMO transferase activity of PIAS4 [nucleoplasm] PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4006002] May, B, 2013-07-24
edited	[InstanceEdit:3968435] May, B, 2013-07-23
input	[Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4006003] Smad3 [nucleoplasm] [Mus musculus]
isChimeric	TRUE
literatureReference	[LiteratureReference:4006015] Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3 [LiteratureReference:4005996] Sumoylation of Smad3 stimulates its nuclear export during PIASy-mediated suppression of TGF-beta signaling
modified	[InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8936028] May, Bruce, 2016-08-16 [InstanceEdit:8936036] May, Bruce, 2016-08-16 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762281] May, Bruce, 2022-01-19
name	PIAS4 SUMOylates Smad3 with SUMO1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4005959] monoSUMO1-Smad3 [nucleoplasm] [Mus musculus]
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:8901052] R-NUL-4006035.1
summation	[Summation:4005987] Human PIAS4 SUMOylates mouse Smad3 at an unknown lysine resi...
(inferredFrom)	[Reaction:4005964] PIAS4 SUMOylates SMAD3 with SUMO1 [Homo sapiens]
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No pathways have been reviewed or authored by PIAS4 SUMOylates Smad3 with SUMO1 (4006035)