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Details on Person Expression of BMAL1 (ARNTL)

Class:Id	BlackBoxEvent:400342
_displayName	Expression of BMAL1 (ARNTL)
_doRelease	TRUE
_timestamp	2025-02-19 18:59:01
authored	[InstanceEdit:421369] May, B, 2009-05-17 22:04:50
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:400303] May, B, 2009-03-24 02:57:07
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
inferredFrom	[BlackBoxEvent:508681] Expression of Bmal1 (Arntl) [Mus musculus]
input	[EntityWithAccessionedSequence:5640173] ARNTL gene [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:549415] cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage [LiteratureReference:879738] Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
modified	[InstanceEdit:421334] May, B, 2009-05-17 21:28:13 [InstanceEdit:421369] May, B, 2009-05-17 22:04:50 [InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:425305] May, B, 2009-06-03 [InstanceEdit:425748] May, B, 2009-06-05 [InstanceEdit:425874] May, B, 2009-06-08 [InstanceEdit:425941] Matthews, L, 2009-06-09 [InstanceEdit:434265] May, B, 2009-08-27 [InstanceEdit:435278] May, B, 2009-09-09 [InstanceEdit:508676] May, B, 2010-02-15 [InstanceEdit:549380] May, B, 2010-03-21 [InstanceEdit:766127] May, B, 2010-05-21 [InstanceEdit:847704] May, B, 2010-05-30 [InstanceEdit:879757] May, B, 2010-06-23 [InstanceEdit:927716] May, B, 2010-08-06 [InstanceEdit:1801592] May, B, 2011-10-24 [InstanceEdit:5640212] May, Bruce, 2014-11-16 [InstanceEdit:5663276] May, Bruce, 2015-01-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9707568] Stephan, Ralf, 2020-11-19 [InstanceEdit:9713328] Stephan, Ralf, 2021-01-25 [InstanceEdit:9717154] May, Bruce, 2021-03-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9936592] May, Bruce, 2025-01-24 [InstanceEdit:9938770] May, Bruce, 2025-02-19 [InstanceEdit:9938788] May, Bruce, 2025-02-19
name	Expression of BMAL1 (ARNTL) ARNTL gene produces ARNTL
output	[EntityWithAccessionedSequence:400353] ARNTL [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9911560] RORA,B,C, EP300, PPARGC1A, NRIP1 bind BMAL1 (ARNTL) gene [Homo sapiens] [BlackBoxEvent:1368140] Expression of PPARGC1A (PGC-1alpha) [Homo sapiens] [BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:400375] Positive gene expression regulation by 'RORA:Coactivator:ARNTL gene [nucleoplasm]' [NegativeGeneExpressionRegulation:421342] Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5656526] Positive gene expression regulation by 'SIRT1 [nucleoplasm]'
regulationReference	[RegulationReference:9641789] Positive gene expression regulation by 'SIRT1 [nucleoplasm]' SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging [RegulationReference:9642203] Positive gene expression regulation by 'RORA:Coactivator:ARNTL gene [nucleoplasm]' Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors [RegulationReference:9643028] Negative gene expression regulation by 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta
releaseDate	2010-09-21
reviewed	[InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:9713327] Somers, Julia, 2021-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105269] R-HSA-400342.8
summation	[Summation:400357] The ARNTL (BMAL1) gene is transcribed to yield mRNA and the ... [Summation:400221] NR1D1 (REV-ERBA) binds to the same site in the promoter of t... [Summation:549489] As inferred from mouse, RORA binds RRE DNA elements and recr...
(hasEvent)	[Pathway:9707616] Heme signaling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775954] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v78:[addSummation] [_UpdateTracker:9776158] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v77:[modifyText] [_UpdateTracker:9776288] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v76:[modifyText] [_UpdateTracker:9784899] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v52:[add_removeRegulator] [_UpdateTracker:9785834] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v51:[addInput] [_UpdateTracker:9789094] Update Tracker - [BlackBoxEvent:400342] Expression of ARNTL (BMAL1) - v38:[add_removeRegulator]
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No pathways have been reviewed or authored by Expression of BMAL1 (ARNTL) (400342)