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Details on Person Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression

Class:IdLiteratureReference:400260
_displayNameCryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression
_timestamp2009-03-24 03:06:54
author[Person:400243] Dardente, H
[Person:400350] Fortier, EE
[Person:400339] Martineau, V
[Person:400355] Cermakian, N
created[InstanceEdit:400303] May, B, 2009-03-24 02:57:07
journalBiochem J
pages525-36
pubMedIdentifier17115977
titleCryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression
volume402
year2007
(literatureReference)[Reaction:508619] Bmal1 binds Clock,Npas2 forming Bmal1:Clock,Npas2 heterodimer [Mus musculus]
[Reaction:549451] Cry proteins stabilize unphosphorylated Bmal1:Clock,Npas2 [Mus musculus]
[BlackBoxEvent:9909564] Phosphorylated Bmal1:Clock,Npas2 and coactivators positively regulate expression of Period-1 (Per1) [Mus musculus]
[Complex:421315] p-BMAL1:p-CLOCK,NPAS2 [nucleoplasm] [Homo sapiens]
[Complex:508608] p-Bmal1:p-Clock,Npas2 [nucleoplasm] [Mus musculus]
[Complex:508648] Bmal1:Clock,Npas2 [cytosol] [Mus musculus]
[Complex:549343] Bmal1:Clock,Npas2:Cry [cytosol] [Mus musculus]
[Complex:9859895] Ac-K538,p-BMAL1:p-CLOCK [nucleoplasm] [Homo sapiens]
[Complex:9859913] Ac-K544,p-Bmal1:p-Clock [nucleoplasm] [Mus musculus]
[Complex:9932295] p-S365,T371-Arntl2:p-T451,T461-Clock [nucleoplasm] [Mus musculus]
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No pathways have been reviewed or authored by Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression (400260)