Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
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Details on Person FBXL3 is an F-box type component of a particular SKP/CUL/F-B...
| Class:Id | Summation:400226 |
|---|---|
| _displayName | FBXL3 is an F-box type component of a particular SKP/CUL/F-B... |
| _timestamp | 2010-06-23 02:00:17 |
| created | [InstanceEdit:400303] May, B, 2009-03-24 02:57:07 |
| modified | [InstanceEdit:879757] May, B, 2010-06-23 |
| text | FBXL3 is an F-box type component of a particular SKP/CUL/F-Box E3 ubiquitin ligase. FBXL3 interacts specifically with CRY1 and CRY2 in the cytosol to direct the polyubiquitination of CRY1 and CRY2. It is unknown if FBXL3 requires phosphorylation or other modification of CRY proteins in order to bind and ubiquitinate them. Phosphorylation of CRY by Adenosine monophosphate-dependent kinase increases degradation of CRY, apparently by increasing association of CRY with FBXL3 Polyubiquitination of CRY proteins directs them to the 26S proteasome for degradation. |
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No pathways have been reviewed or authored by FBXL3 is an F-box type component of a particular SKP/CUL/F-B... (400226)
