Query author contributions in Reactome
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Details on Person NR1D1 (REV-ERBA) binds to the same site in the promoter of t...
| Class:Id | Summation:400221 |
|---|---|
| _displayName | NR1D1 (REV-ERBA) binds to the same site in the promoter of t... |
| _timestamp | 2013-06-02 02:44:41 |
| created | [InstanceEdit:400303] May, B, 2009-03-24 02:57:07 |
| modified | [InstanceEdit:421328] May, B, 2009-05-17 21:26:07 [InstanceEdit:421362] May, B, 2009-05-17 22:04:08 [InstanceEdit:1368132] May, B, 2011-06-29 [InstanceEdit:3656300] May, B, 2013-06-02 |
| text | NR1D1 (REV-ERBA) binds to the same site in the promoter of the BMAL1 (ARNTL) gene as ROR-alpha (RORA). Whereas ROR-alpha activates transcription of BMAL1, REV-ERBA bound to heme recruits corepressors (NCoR and HDAC3) and inhibits transcription of BMAL1. Both REV-ERBA and ROR-alpha genes are targets of BMAL1:CLOCK/NPAS2 transactivation and they show alternating patterns of maximum protein levels, thus they give BMAL1 transcription circadian expression. |
| (summation) | [BlackBoxEvent:400342] Expression of BMAL1 (ARNTL) [Homo sapiens] |
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No pathways have been reviewed or authored by NR1D1 (REV-ERBA) binds to the same site in the promoter of t... (400221)
