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Details on Person PPARA binds RXRA

Class:Id	Reaction:400204
_displayName	PPARA binds RXRA
_doRelease	TRUE
_timestamp	2025-08-13 19:23:47
authored	[InstanceEdit:422414] May, B, 2009-05-30 16:45:51
catalystActivity	[CatalystActivity:9960248] RNA polymerase II cis-regulatory region sequence-specific DNA binding activity of RXRA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:400195] May, B, 2009-03-24 02:23:25
edited	[InstanceEdit:422414] May, B, 2009-05-30 16:45:51 [InstanceEdit:425907] May, B, 2009-06-08
input	[EntityWithAccessionedSequence:400186] PPARA [nucleoplasm] [Homo sapiens] [OtherEntity:422139] Peroxisome Proliferator Receptor Element (PPRE) [nucleoplasm] [EntityWithAccessionedSequence:381319] RXRA [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9954135] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9960254] D'Eustachio, Peter, 2025-07-08
literatureReference	[LiteratureReference:400173] PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene [LiteratureReference:400106] From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions [LiteratureReference:400147] Peroxisome proliferator activated receptors and lipoprotein metabolism [LiteratureReference:400187] Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis [LiteratureReference:400127] Peroxisome proliferator-activated receptors: nuclear control of metabolism [LiteratureReference:400211] Peroxisome proliferator-activated receptors, coactivators, and downstream targets
modified	[InstanceEdit:422133] May, B, 2009-05-26 17:27:03 [InstanceEdit:422146] May, B, 2009-05-26 17:29:32 [InstanceEdit:422157] D'Eustachio, P, 2009-05-26 22:31:35 [InstanceEdit:422559] D'Eustachio, P, 2009-06-02 01:19:11 [InstanceEdit:425908] May, B, 2009-06-08 [InstanceEdit:434269] May, B, 2009-08-27 [InstanceEdit:983112] May, B, 2010-10-29 [InstanceEdit:2026094] May, B, 2011-12-22 [InstanceEdit:2026995] May, B, 2011-12-23 [InstanceEdit:5251386] May, B, 2014-02-03 [InstanceEdit:5251722] May, B, 2014-02-04 [InstanceEdit:5252147] May, B, 2014-02-05 [InstanceEdit:9734514] Jassal, Bijay, 2021-06-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9954125] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9954136] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9956891] D'Eustachio, Peter, 2025-06-16 [InstanceEdit:9960250] D'Eustachio, Peter, 2025-07-08 [InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08 [InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
name	PPARA binds RXRA PPARA binds RXRA forming PPARA:RXRA heterodimer at promoter of target gene
output	[Complex:400138] PPARA:RXRA heterodimer [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:879724] Expression of PPARA [Homo sapiens] [Reaction:5663156] p-S90-BMAL1:p-T451,T461-CLOCK binds PPARA gene [Homo sapiens] [BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [Reaction:2026996] FABP1 transports fatty acids into the nucleus [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2009-09-30
reviewed	[InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:9956890] Hill, David P, 2025-06-16 [InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104195] R-HSA-400204.4
structureModified	[InstanceEdit:9954125] D'Eustachio, Peter, 2025-06-06 [InstanceEdit:9960250] D'Eustachio, Peter, 2025-07-08
summation	[Summation:400151] Peroxisome proliferator-activated receptor alpha (PPAR-alpha...
(hasEvent)	[Pathway:400206] Regulation of lipid metabolism by PPARalpha [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788735] Update Tracker - [Reaction:400204] PPARA binds RXRA - v40:[add_removeInput] [_UpdateTracker:9964693] Update Tracker - [Reaction:400204] PPARA binds RXRA - v94:[removeCatalystActivity]
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No pathways have been reviewed or authored by PPARA binds RXRA (400204)