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Details on Person PPARA:RXRA binds Corepressors of PPARA

Class:IdBlackBoxEvent:400183
_displayNamePPARA:RXRA binds Corepressors of PPARA
_doReleaseTRUE
_timestamp2025-08-13 19:23:49
authored[InstanceEdit:422414] May, B, 2009-05-30 16:45:51
catalystActivity[CatalystActivity:9960251] transcription corepressor activity of Corepressors of PPARalpha [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:400195] May, B, 2009-03-24 02:23:25
edited[InstanceEdit:422414] May, B, 2009-05-30 16:45:51
[InstanceEdit:425907] May, B, 2009-06-08
goBiologicalProcess[GO_BiologicalProcess:422887] negative regulation of transcription initiation by RNA polymerase II
input[DefinedSet:400207] Corepressors of PPARalpha [nucleoplasm] [Homo sapiens]
[Complex:400138] PPARA:RXRA heterodimer [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:351644] TBL1X [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:351643] TBL1XR1 [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9960254] D'Eustachio, Peter, 2025-07-08
literatureReference[LiteratureReference:400106] From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
[LiteratureReference:400147] Peroxisome proliferator activated receptors and lipoprotein metabolism
[LiteratureReference:400187] Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis
[LiteratureReference:400127] Peroxisome proliferator-activated receptors: nuclear control of metabolism
[LiteratureReference:400133] A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin
[LiteratureReference:400211] Peroxisome proliferator-activated receptors, coactivators, and downstream targets
modified[InstanceEdit:422133] May, B, 2009-05-26 17:27:03
[InstanceEdit:422157] D'Eustachio, P, 2009-05-26 22:31:35
[InstanceEdit:422414] May, B, 2009-05-30 16:45:51
[InstanceEdit:422559] D'Eustachio, P, 2009-06-02 01:19:11
[InstanceEdit:425914] May, B, 2009-06-08
[InstanceEdit:434270] May, B, 2009-08-27
[InstanceEdit:5251386] May, B, 2014-02-03
[InstanceEdit:9734514] Jassal, Bijay, 2021-06-17
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9954125] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9960250] D'Eustachio, Peter, 2025-07-08
[InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08
[InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
namePPARA:RXRA binds Corepressors of PPARA
output[Complex:400196] PPARA:RXRA:Corepressors [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2009-09-30
reviewed[InstanceEdit:425906] Kersten, S, 2009-06-08
[InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104566] R-HSA-400183.4
structureModified[InstanceEdit:9960250] D'Eustachio, Peter, 2025-07-08
summation[Summation:400189] In the absence of activating ligands of PPAR-alpha, the PPAR...
(hasEvent)[Pathway:400206] Regulation of lipid metabolism by PPARalpha [Homo sapiens]
(precedingEvent)[BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens]
[Reaction:9734475] PPARA binds fibrates [Homo sapiens]
(updatedInstance)[_UpdateTracker:9964685] Update Tracker - [BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA - v94:[removeCatalystActivity]
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No pathways have been reviewed or authored by PPARA:RXRA binds Corepressors of PPARA (400183)
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