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Details on Person The set of genes regulated by PPAR-alpha is not fully known ...
| Class:Id | Summation:400179 |
|---|---|
| _displayName | The set of genes regulated by PPAR-alpha is not fully known ... |
| _timestamp | 2011-11-19 08:41:03 |
| created | [InstanceEdit:400195] May, B, 2009-03-24 02:23:25 |
| modified | [InstanceEdit:425916] May, B, 2009-06-08 [InstanceEdit:1990838] May, B, 2011-11-14 [InstanceEdit:1998760] May, B, 2011-11-19 |
| text | The set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor elements (PPREs) in their promoters and include: 1) genes involved in fatty acid oxidation and ketogenesis (Acox1, Cyp4a, Acadm, Hmgcs2); 2) genes involved in fatty acid transport (Cd36, , Slc27a1, Fabp1, Cpt1a, Cpt2); 3) genes involved in producing fatty acids and very low density lipoproteins (Me1, Scd1); 4) genes encoding apolipoproteins (Apoa1, Apoa2, Apoa5); 5) genes involved in triglyceride clearance ( Angptl4); 6) genes involved in glycerol metabolism (Gpd1 in mouse); 7) genes involved in glucose metabolism (Pdk4); 8) genes involved in peroxisome proliferation (Pex11a); 9) genes involved in lipid storage (Plin, Adfp). Many other genes are known to be regulated by PPAR-alpha but whether their regulation is direct or indirect remains to be found. These genes include: ACACA, FAS, SREBP1, FADS1, DGAT1, ABCA1, PLTP, ABCB4, UGT2B4, SULT2A1, Pnpla2, Acsl1, Slc27a4, many Acot genes, and others (reviewed in Rakhshandehroo et al. 2010). |
| (summation) | [Pathway:1989781] PPARA activates gene expression [Homo sapiens] |
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