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Details on Person PPAR-alpha is activated by binding polyunsaturated fatty aci...
| Class:Id | Summation:400148 |
|---|---|
| _displayName | PPAR-alpha is activated by binding polyunsaturated fatty aci... |
| _timestamp | 2025-06-06 20:56:24 |
| created | [InstanceEdit:400195] May, B, 2009-03-24 02:23:25 |
| modified | [InstanceEdit:422134] May, B, 2009-05-26 17:27:28 [InstanceEdit:425911] May, B, 2009-06-08 [InstanceEdit:9709902] Stephan, Ralf, 2020-12-18 [InstanceEdit:9954125] D'Eustachio, Peter, 2025-06-06 |
| text | PPAR-alpha is activated by binding polyunsaturated fatty acids especially those having 18-22 carbon groups and 2-6 double bonds such as linoleiate, linolenate, arachidonate, and eicosapentaenoate. These ligands bind the C-terminal region of PPAR-alpha. The fibrate drugs are also agonists of PPAR-alpha. Binding of a ligand causes a conformational change in PPAR-alpha so that it recruits coactivators. By analogy with the closely related receptor PPAR-gamma, PPAR-alpha probably binds TBL1 and TBLR1, which are responsible for recruiting the 19S proteasome to degrade corepressors during the exchange of corepressors for coactivators. The coactivators belong to the CBP-SRC-HAT complex (CBP/p300, SRC1, SRC2, SRC3, CARM1, SWI/SNF, BAF60C, PRIC320, and PRIC285), the ASC complex (PRIP/ASC2, PIMT), and the TRAP-DRIP-ARC-MEDIATOR complex (TRAP130, PBP/TRAP220). The coactivators contain LXXLL motifs (Nuclear Receptor Boxes) that interact with the AF-2 region in nuclear receptors such as PPAR-alpha. Additionally bilirubin binds to PPAR-alpha and acts as coactivator. |
| (summation) | [BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] |
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No pathways have been reviewed or authored by PPAR-alpha is activated by binding polyunsaturated fatty aci... (400148)
