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Details on Person CARM1 [nucleoplasm]
Class:Id EntityWithAccessionedSequence:400139
_displayName CARM1 [nucleoplasm]
_timestamp 2014-01-16 14:15:32
compartment [Compartment:7660] nucleoplasm
created [InstanceEdit:400195] May, B, 2009-03-24 02:23:25
endCoordinate 608
modified [InstanceEdit:2026131] May, B, 2011-12-22 [InstanceEdit:3132750] Wu, G, 2013-02-13 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:3700975] Orlic-Milacic, M, 2013-06-11 [InstanceEdit:5229040] Jupe, S, 2014-01-16
name CARM1 Histone-arginine methyltransferase CARM1 CARM1_HUMAN PRMT4
referenceEntity [ReferenceGeneProduct:221315] UniProt:Q86X55 CARM1 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1106090] R-HSA-400139.1
startCoordinate 1
(activeUnit) [PositiveGeneExpressionRegulation:3215147] Positive gene expression regulation by 'p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm]'
(hasComponent) [Complex:3215149] p-S15,S20-TP53:EP300:PRMT1:CARM1:GADD45A Gene [nucleoplasm] [Homo sapiens] [Complex:9009534] CARM1:TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] [Homo sapiens]
(hasMember) [DefinedSet:400216] Coactivators of PPARalpha [nucleoplasm] [Homo sapiens] [DefinedSet:5244524] CARM1, PRMT6 [nucleoplasm] [Homo sapiens]
(input) [Reaction:3215152] TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter [Homo sapiens] [FailedReaction:3701014] TP53 R175H does not bind GADD45A promoter [Homo sapiens] [Reaction:9009526] CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene [Homo sapiens]
(output) [BlackBoxEvent:9677873] CARM1 gene expression is positively regulated by WDR5 and MYC [Homo sapiens]
(physicalEntity) [CatalystActivity:5229055] protein-arginine N-methyltransferase activity of CARM1 [nucleoplasm]
(updatedInstance) [_UpdateTracker:9876615] Update Tracker - [EntityWithAccessionedSequence:400139] CARM1 [nucleoplasm] - v44:[addEndCoordinate, addStartCoordinate] [_UpdateTracker:9883733] Update Tracker - [EntityWithAccessionedSequence:400139] CARM1 [nucleoplasm] - v45:[addName] [_UpdateTracker:9888313] Update Tracker - [EntityWithAccessionedSequence:400139] CARM1 [nucleoplasm] - v46:[modifyStartCoordinate, removeName] [_UpdateTracker:9888801] Update Tracker - [EntityWithAccessionedSequence:400139] CARM1 [nucleoplasm] - v48:[addName]
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Pathways
No pathways have been reviewed or authored by CARM1 [nucleoplasm] (400139)