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Details on Person Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits

Class:IdLiteratureReference:400089
_displayNameDirect control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits
_timestamp2009-03-24 02:04:18
author[Person:264259] Lang, J
[Person:400052] Nishimoto, I
[Person:400075] Okamoto, T
[Person:264296] Regazzi, R
[Person:400081] Kiraly, C
[Person:264320] Weller, Ulrich
[Person:186496] Wollheim, CB
created[InstanceEdit:400084] May, B, 2009-03-24 01:57:51
journalEMBO J
pages3635-44
pubMedIdentifier7641683
titleDirect control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits
volume14
year1995
(literatureReference)[BlackBoxEvent:265166] Exocytosis of Insulin [Homo sapiens]
[Reaction:400037] Gi,Go Heterotrimeric G-protein complex dissociates [Homo sapiens]
[Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion [Homo sapiens]
[BlackBoxEvent:400046] L-type Calcium Channels close in pancreatic beta cells [Homo sapiens]
[BlackBoxEvent:400063] Low conductance potassium channels in pancreatic beta cells open in response to epinephrine [Homo sapiens]
[Reaction:400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline [Homo sapiens]
[Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins [Homo sapiens]
[Reaction:400097] G-beta:G-gamma inhibits Adenylate cyclase [Homo sapiens]
[RegulationReference:9642641] Negative regulation by 'Voltage-gated Calcium Channels Type Cav1 (closed) [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel
[RegulationReference:9642657] Negative regulation by 'G-alpha(i,o):GTP [plasma membrane]' Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel
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No pathways have been reviewed or authored by Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits (400089)