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Details on Person Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline

Class:Id	Reaction:400071
_displayName	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline
_doRelease	TRUE
_timestamp	2024-02-12 20:42:35
authored	[InstanceEdit:422245] May, B, 2009-05-27 03:41:50
catalystActivity	[CatalystActivity:400033] alpha2-adrenergic receptor activity of ADRA2A,C [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9860675] alpha2-adrenergic receptor activity of ADRA2A,C [plasma membrane] An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:400084] May, B, 2009-03-24 01:57:51
edited	[InstanceEdit:422244] May, B, 2009-05-27 03:41:38
input	[DefinedSet:400086] ADRA2A,C [plasma membrane] [Homo sapiens] [DefinedSet:390627] ADR, NAd [extracellular region]
literatureReference	[LiteratureReference:446440] Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans [LiteratureReference:446443] Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans [LiteratureReference:446428] Subtype-specific stimulation of [35S]GTPgammaS binding by recombinant alpha2-adrenoceptors [LiteratureReference:400054] Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel [LiteratureReference:400089] Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400059] Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice [LiteratureReference:400072] Mechanisms of inhibition of insulin release [LiteratureReference:9860663] An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling
modified	[InstanceEdit:422155] D'Eustachio, P, 2009-05-26 22:24:41 [InstanceEdit:422244] May, B, 2009-05-27 03:41:38 [InstanceEdit:422547] D'Eustachio, P, 2009-06-02 00:48:17 [InstanceEdit:422568] D'Eustachio, P, 2009-06-02 [InstanceEdit:425261] May, B, 2009-06-03 [InstanceEdit:446438] May, B, 2009-11-13 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:8951478] May, Bruce, 2016-12-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline
output	[Complex:400090] ADRA2A,C:ADR,NAd [plasma membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422547] D'Eustachio, P, 2009-06-02 00:48:17 [InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104365] R-HSA-400071.4
structureModified	[InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09
summation	[Summation:400079] The pancreatic beta cell contains Alpha2A and Alpha2C Adrene...
(hasEvent)	[Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion [Homo sapiens]
(precedingEvent)	[Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781632] Update Tracker - [Reaction:400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline - v60:[add_removeInput] [_UpdateTracker:9791373] Update Tracker - [Reaction:400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline - v31:[add_removeLiteratureReference] [_UpdateTracker:9864109] Update Tracker - [Reaction:400071] Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline - v88:[addCatalystActivity, addLiteratureReference]
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