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Details on Person Low conductance potassium channels in pancreatic beta cells open in response to epinephrine

Class:Id	BlackBoxEvent:400063
_displayName	Low conductance potassium channels in pancreatic beta cells open in response to epinephrine
_doRelease	TRUE
_timestamp	2025-06-02 14:56:44
authored	[InstanceEdit:422245] May, B, 2009-05-27 03:41:50
catalystActivity	[CatalystActivity:9946986] potassium channel activator activity of G-alpha(i,o):GTP [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:400084] May, B, 2009-03-24 01:57:51
edited	[InstanceEdit:422245] May, B, 2009-05-27 03:41:50
inferredFrom	[BlackBoxEvent:446503] Opening of Low Conductance Potassium Channels [Mus musculus]
input	[GenomeEncodedEntity:446513] Potassium Channel, closed (pancreatic beta cell) [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9947030] D'Eustachio, Peter, 2025-04-30
literatureReference	[LiteratureReference:400089] Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400059] Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice [LiteratureReference:400072] Mechanisms of inhibition of insulin release
modified	[InstanceEdit:422155] D'Eustachio, P, 2009-05-26 22:24:41 [InstanceEdit:422249] May, B, 2009-05-27 03:43:35 [InstanceEdit:422547] D'Eustachio, P, 2009-06-02 00:48:17 [InstanceEdit:422568] D'Eustachio, P, 2009-06-02 [InstanceEdit:425267] May, B, 2009-06-03 [InstanceEdit:446461] May, B, 2009-11-13 [InstanceEdit:446517] May, B, 2009-11-13 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9946988] D'Eustachio, Peter, 2025-04-29 [InstanceEdit:9947029] D'Eustachio, Peter, 2025-04-30 [InstanceEdit:9953426] D'Eustachio, Peter, 2025-06-02
name	Low conductance potassium channels in pancreatic beta cells open in response to epinephrine
output	[GenomeEncodedEntity:446505] Potassium Channel, open (pancreatic beta cell) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:400037] Gi,Go Heterotrimeric G-protein complex dissociates [Homo sapiens] [Reaction:400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422547] D'Eustachio, P, 2009-06-02 00:48:17 [InstanceEdit:9953425] Hill, David P, 2025-06-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105516] R-HSA-400063.4
structureModified	[InstanceEdit:9946988] D'Eustachio, Peter, 2025-04-29
summation	[Summation:422250] ATP-sensitive Potassium channels open and allow an inward re...
(hasEvent)	[Pathway:400042] Adrenaline,noradrenaline inhibits insulin secretion [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791257] Update Tracker - [BlackBoxEvent:400063] Low conductance potassium channels in pancreatic beta cells open in response to epinephrine - v31:[add_removeInput, add_removeOutput, removeLiteratureReference] [_UpdateTracker:9953737] Update Tracker - [BlackBoxEvent:400063] Low conductance potassium channels in pancreatic beta cells open in response to epinephrine - v93:[addRegulator, removeCatalystActivity]
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