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Details on Person Gq alpha activates Phospholipase C beta

Class:Id	Reaction:400023
_displayName	Gq alpha activates Phospholipase C beta
_doRelease	TRUE
_timestamp	2024-01-29 15:51:25
authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity	[CatalystActivity:9857125] phospholipase activator activity of G-alpha(q) 11,14,15,Q:GTP [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
inferredFrom	[Reaction:445860] Activation of Phospholipase C beta1 by G(q)alpha:GTP [Mus musculus]
input	[Complex:400008] G-alpha(q) 11,14,15,Q:GTP [plasma membrane] [Homo sapiens] [CandidateSet:400005] PLC beta1,2,3 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:375544] Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq [LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function
modified	[InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:422274] May, B, 2009-05-27 19:37:23 [InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15 [InstanceEdit:425229] May, B, 2009-06-03 [InstanceEdit:434310] May, B, 2009-08-28 [InstanceEdit:443052] May, B, 2009-10-02 [InstanceEdit:445863] May, B, 2009-11-06 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9857126] D'Eustachio, Peter, 2024-01-02 [InstanceEdit:9860026] D'Eustachio, Peter, 2024-01-29
name	Gq alpha activates Phospholipase C beta
output	[Complex:400011] PLC beta1,2,3:G-alpha(q):GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:400027] Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma [Homo sapiens] [Reaction:399995] Muscarinic Acetylcholine Receptor M3 activates Gq [Homo sapiens] [Reaction:416530] FFAR1:FFAR1 ligands activate Gq [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9860027] D'Eustachio, Peter, 2024-01-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104883] R-HSA-400023.3
structureModified	[InstanceEdit:9857126] D'Eustachio, Peter, 2024-01-02
summation	[Summation:399975] The Gq alpha:GTP complex activates Phospholipase C beta-1 th...
(hasEvent)	[Pathway:399997] Acetylcholine regulates insulin secretion [Homo sapiens] [Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion [Homo sapiens]
(precedingEvent)	[Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791359] Update Tracker - [Reaction:400023] Gq alpha activates Phospholipase C beta - v31:[modifyText] [_UpdateTracker:9864013] Update Tracker - [Reaction:400023] Gq alpha activates Phospholipase C beta - v88:[addCatalystActivity]
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