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Details on Person Diacylgycerol activates Protein kinase C, alpha type

Class:Id	Reaction:400015
_displayName	Diacylgycerol activates Protein kinase C, alpha type
_doRelease	TRUE
_timestamp	2024-02-12 20:42:38
authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity	[CatalystActivity:9860667] diacylglycerol binding activity of PRKCA [cytosol]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
input	[EntityWithAccessionedSequence:58196] PRKCA [cytosol] [Homo sapiens] [SimpleEntity:114519] DAG [plasma membrane]
literatureReference	[LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function [LiteratureReference:9029472] Interplay between calcium, diacylglycerol, and phosphorylation in the spatial and temporal regulation of PKCalpha-GFP
modified	[InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:422276] May, B, 2009-05-27 19:37:30 [InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15 [InstanceEdit:425230] May, B, 2009-06-03 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9029474] May, Bruce, 2017-11-19 [InstanceEdit:9035259] May, Bruce, 2018-01-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	Diacylgycerol activates Protein kinase C, alpha type
output	[Complex:422275] Protein Kinase C, alpha type: DAG [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Homo sapiens] [Reaction:400023] Gq alpha activates Phospholipase C beta [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104215] R-HSA-400015.4
structureModified	[InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09
summation	[Summation:400019] Diacylglycerol, produced by PLC beta-mediated PIP2 hydrolysi...
(hasEvent)	[Pathway:399997] Acetylcholine regulates insulin secretion [Homo sapiens] [Pathway:2179392] EGFR Transactivation by Gastrin [Homo sapiens]
(precedingEvent)	[Reaction:399978] Protein kinase C, alpha type phosphorylates MARCKS [Homo sapiens] [BlackBoxEvent:2179413] Activated PKC-alpha activate MMP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779788] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v64:[addLiteratureReference] [_UpdateTracker:9788536] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v41:[modifyText] [_UpdateTracker:9864287] Update Tracker - [Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type - v88:[addCatalystActivity]
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