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Details on Person Acetylcholine binds Muscarinic Acetylcholine Receptor M3

Class:Id	Reaction:400012
_displayName	Acetylcholine binds Muscarinic Acetylcholine Receptor M3
_doRelease	TRUE
_timestamp	2024-02-12 20:42:31
authored	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity	[CatalystActivity:9860670] G protein-coupled acetylcholine receptor activity of CHRM3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9860664] G protein-coupled acetylcholine receptor activity of CHRM3 [plasma membrane] A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
edited	[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
inferredFrom	[Reaction:426560] Binding of Acetylcholine by Muscarinic Acetylcholine Receptor M3 [Mus musculus]
input	[SimpleEntity:372533] AcCho [extracellular region] [EntityWithAccessionedSequence:399994] CHRM3 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:426544] A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400003] Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis [LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function
modified	[InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:422278] May, B, 2009-05-27 19:37:41 [InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15 [InstanceEdit:425231] May, B, 2009-06-03 [InstanceEdit:426563] May, B, 2009-06-16 [InstanceEdit:445866] May, B, 2009-11-06 [InstanceEdit:749481] May, B, 2010-05-19 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09 [InstanceEdit:9860913] D'Eustachio, Peter, 2024-02-12
name	Acetylcholine binds Muscarinic Acetylcholine Receptor M3
output	[Complex:400013] Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-06-24
reviewed	[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 [InstanceEdit:9860914] Hill, David P, 2024-02-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104207] R-HSA-400012.3
structureModified	[InstanceEdit:9860666] D'Eustachio, Peter, 2024-02-09
summation	[Summation:399991] Intrapancreatic parasympathetic (vagal) nerve endings releas...
(hasEvent)	[Pathway:399997] Acetylcholine regulates insulin secretion [Homo sapiens]
(precedingEvent)	[Reaction:399995] Muscarinic Acetylcholine Receptor M3 activates Gq [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790661] Update Tracker - [Reaction:400012] Acetylcholine binds Muscarinic Acetylcholine Receptor M3 - v33:[add_removeInput, add_removeOutput] [_UpdateTracker:9791405] Update Tracker - [Reaction:400012] Acetylcholine binds Muscarinic Acetylcholine Receptor M3 - v30:[addLiteratureReference] [_UpdateTracker:9864090] Update Tracker - [Reaction:400012] Acetylcholine binds Muscarinic Acetylcholine Receptor M3 - v88:[addCatalystActivity]
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