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Details on Person Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

Class:IdReaction:399998
_displayNameActivated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
_doReleaseTRUE
_timestamp2025-06-02 14:56:31
authored[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
catalystActivity[CatalystActivity:400007] C-type glycerophospholipase activity of PLC beta1,2,3:G-alpha(q):GTP [plasma membrane]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:399979] May, B, 2009-03-24 01:48:37
crossReference[DatabaseIdentifier:9947018] RHEA:33180
edited[InstanceEdit:422341] May, B, 2009-05-28 03:44:04
input[SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9947030] D'Eustachio, Peter, 2025-04-30
literatureReference[LiteratureReference:140093] Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets
[LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function
modified[InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55
[InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15
[InstanceEdit:425233] May, B, 2009-06-03
[InstanceEdit:432729] May, B, 2009-08-15
[InstanceEdit:434312] May, B, 2009-08-28
[InstanceEdit:2851312] Jupe, S, 2012-12-13
[InstanceEdit:5252146] May, B, 2014-02-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30
[InstanceEdit:9947029] D'Eustachio, Peter, 2025-04-30
[InstanceEdit:9953426] D'Eustachio, Peter, 2025-06-02
nameActivated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
output[SimpleEntity:114520] I(1,4,5)P3 [cytosol]
[SimpleEntity:114519] DAG [plasma membrane]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2009-06-24
reviewed[InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21
[InstanceEdit:9953425] Hill, David P, 2025-06-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104245] R-HSA-399998.3
structureModified[InstanceEdit:9947017] D'Eustachio, Peter, 2025-04-30
summation[Summation:179088] Phospholipase C beta-1 associated with the G(q) complex in t...
(hasEvent)[Pathway:399997] Acetylcholine regulates insulin secretion [Homo sapiens]
[Pathway:434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion [Homo sapiens]
(precedingEvent)[Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Homo sapiens]
[Reaction:400015] Diacylgycerol activates Protein kinase C, alpha type [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787776] Update Tracker - [Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - v44:[add_removeInput]
[_UpdateTracker:9791320] Update Tracker - [Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - v31:[modifyText]
[_UpdateTracker:9791392] Update Tracker - [Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - v30:[addInput]
[_UpdateTracker:9953714] Update Tracker - [Reaction:399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - v93:[removeOutput]
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