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Details on Person Muscarinic Acetylcholine Receptor M3 activates Gq
Class:Id Reaction:399995 _displayName Muscarinic Acetylcholine Receptor M3 activates Gq _doRelease TRUE _timestamp 2014-02-05 19:43:25 authored [InstanceEdit:422341] May, B, 2009-05-28 03:44:04 catalystActivity [CatalystActivity:749482] guanyl-nucleotide exchange factor activity of Muscarinic Acetylcholine Receptor M3:Acetylcholine Complex [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:399979] May, B, 2009-03-24 01:48:37 edited [InstanceEdit:422341] May, B, 2009-05-28 03:44:04 inferredFrom
input [SimpleEntity:29438] GTP [cytosol] [Complex:399992] G-alpha(q)11,14,15,Q:GDP:G-beta:G-gamma [plasma membrane] [Homo sapiens] literatureReference [LiteratureReference:426544] A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo [LiteratureReference:445851] Peptide fragment of the m3 muscarinic acetylcholine receptor activates G(q) but not G(i2) [LiteratureReference:445843] Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein [LiteratureReference:445847] Antisense co-suppression of G(alpha)(q) and G(alpha)(11) demonstrates that both isoforms mediate M(3)-receptor-activated Ca(2+) signalling in intact epithelial cells [LiteratureReference:445836] Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11 [LiteratureReference:381633] G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes [LiteratureReference:400003] Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis [LiteratureReference:399990] Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function modified [InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55 [InstanceEdit:422273] May, B, 2009-05-27 19:37:10 [InstanceEdit:422553] D'Eustachio, P, 2009-06-02 00:57:15 [InstanceEdit:425228] May, B, 2009-06-03 [InstanceEdit:426557] May, B, 2009-06-16 [InstanceEdit:445845] May, B, 2009-11-06 [InstanceEdit:749481] May, B, 2010-05-19 [InstanceEdit:5252146] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Muscarinic Acetylcholine Receptor M3 activates Gq output [SimpleEntity:29420] GDP [cytosol] [Complex:399987] G-alpha(q)11,14,15,Q:G-beta:G-gamma [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2009-06-24 reviewed [InstanceEdit:422554] Gillespie, ME, 2009-06-02 00:56:21 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1105215] R-HSA-399995.2 summation [Summation:399982] The binding of acetylcholine to the Muscarinic Acetylcholine... (hasEvent) [Pathway:399997] Acetylcholine regulates insulin secretion [Homo sapiens] (precedingEvent) [Reaction:400027] Gq alpha:G beta:G gamma dissociates to Gq alpha:GTP and G beta:G gamma [Homo sapiens] (updatedInstance) [_UpdateTracker:9790348] Update Tracker - [Reaction:399995] Muscarinic Acetylcholine Receptor M3 activates Gq - v33:[addCatalystActivity, add_removeInput, add_removeOutput] [_UpdateTracker:9791319] Update Tracker - [Reaction:399995] Muscarinic Acetylcholine Receptor M3 activates Gq - v31:[addLiteratureReference] [_UpdateTracker:9791387] Update Tracker - [Reaction:399995] Muscarinic Acetylcholine Receptor M3 activates Gq - v30:[addLiteratureReference]
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