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Details on Person LARG activation by G alpha 12/13

Class:Id	Reaction:398184
_displayName	LARG activation by G alpha 12/13
_doRelease	TRUE
_timestamp	2013-01-10 13:01:00
authored	[InstanceEdit:398140] Jupe, S, 2009-03-18 10:07:56
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:398183] Jupe, S, 2009-03-18 10:29:21
edited	[InstanceEdit:435388] Jupe, S, 2009-09-09
input	[DefinedSet:418572] G-protein alpha (12/13):GTP [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:416560] ARHGEF12 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:437254] Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF
modified	[InstanceEdit:400583] Jupe, S, 2009-03-24 10:18:39 [InstanceEdit:422130] Jassal, Bijay, 2009-05-26 [InstanceEdit:429022] Jupe, S, 2009-07-14 [InstanceEdit:430235] Jupe, S, 2009-08-05 [InstanceEdit:435193] Jupe, S, 2009-09-07 [InstanceEdit:435389] Jupe, S, 2009-09-09 [InstanceEdit:437252] Jupe, S, 2009-09-14 [InstanceEdit:751025] Jupe, S, 2010-05-19 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:2976618] Jupe, S, 2013-01-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LARG activation by G alpha 12/13
output	[Complex:398145] G-protein alpha (12/13):LARG [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:380073] Liganded Gi-activating GPCR acts as a GEF for Gi [Homo sapiens] [Reaction:749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi [Homo sapiens] [Reaction:397891] Thrombin-activated PARs:G12/13 (active) dissociate [Homo sapiens] [Reaction:114552] Thrombin-activated PARs activate G12/13 [Homo sapiens] [Reaction:428918] Dissociation of the TP:G13 complex [Homo sapiens] [Reaction:428917] G13 activation by TP receptor [Homo sapiens] [Reaction:751019] The Ligand:GPCR:G12/13 complex dissociates [Homo sapiens] [Reaction:751029] Liganded G12/13-activating GPCR acts as a GEF for G12/13 [Homo sapiens]
releaseDate	2009-09-30
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104441] R-HSA-398184.2
summation	[Summation:398174] Leukemia-associated RhoGEF (LARG) serves as a G alpha respon...
(hasEvent)	[Pathway:416482] G alpha (12/13) signalling events [Homo sapiens]
(precedingEvent)	[Reaction:398185] LARG binds plexin B1 [Homo sapiens] [Reaction:419166] GEFs activate RhoA,B,C [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788042] Update Tracker - [Reaction:398184] LARG activation by G alpha 12/13 - v44:[add_removeInput] [_UpdateTracker:9790491] Update Tracker - [Reaction:398184] LARG activation by G alpha 12/13 - v33:[add_removeInput]
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