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Details on Person Leukemia-associated RhoGEF (LARG) serves as a G alpha respon...

Class:IdSummation:398174
_displayNameLeukemia-associated RhoGEF (LARG) serves as a G alpha respon...
_timestamp2016-03-17 12:28:08
created[InstanceEdit:398172] Jupe, S, 2009-03-18 10:25:37
literatureReference[LiteratureReference:165196] The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
[LiteratureReference:437279] Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11
[LiteratureReference:437268] Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase
[LiteratureReference:398175] Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells
modified[InstanceEdit:416479] Jupe, S, 2009-03-27 13:04:15
[InstanceEdit:437270] Jupe, S, 2009-09-14
[InstanceEdit:8864974] Jupe, Steve, 2016-03-17
textLeukemia-associated RhoGEF (LARG) serves as a G alpha responsive RhoGEF for G alpha 12, 13 and possibly G alpha q. G alpha 12 activity appears to depend on LARG tyrosine phosphorylation by Tec-family kinases (Suzuki et al. 2003) or FAK (Chikumi et al. 2002). The involvement of LARG may be specific to particular receptor signalling pathways; RNAi-mediated knockdown of LARG specifically inhibited thrombin signaling via PAR1 but not LPA receptors (Wang et al 2004).
(summation)[Reaction:398184] LARG activation by G alpha 12/13 [Homo sapiens]
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