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Details on Person Thrombin-activated PARs:G12/13 (active) dissociate

Class:IdReaction:397891
_displayNameThrombin-activated PARs:G12/13 (active) dissociate
_doReleaseTRUE
_timestamp2020-12-02 14:23:34
authored[InstanceEdit:435013] Akkerman, JW, 2009-09-04
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:397892] Jupe, S, 2009-03-13 15:58:15
edited[InstanceEdit:870306] Jupe, S, 2010-06-07
input[Complex:397884] Thrombin activated PAR:G12/13 (active) [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified[InstanceEdit:398100] Jupe, S, 2009-03-16 17:29:26
[InstanceEdit:398204] D'Eustachio, P, 2009-03-18 14:20:40
[InstanceEdit:400660] Jupe, S, 2009-03-24 17:26:12
[InstanceEdit:416494] Jupe, S, 2009-03-27 14:27:13
[InstanceEdit:421605] Jupe, S, 2009-05-19 09:29:59
[InstanceEdit:428737] Jupe, S, 2009-07-08
[InstanceEdit:456917] Jupe, S, 2010-01-22
[InstanceEdit:870420] Jupe, S, 2010-06-08
[InstanceEdit:938703] Jupe, S, 2010-08-31
[InstanceEdit:8981176] Duenas, Corina, 2017-03-03
[InstanceEdit:9708864] Jassal, Bijay, 2020-12-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameThrombin-activated PARs:G12/13 (active) dissociate
output[DefinedSet:418572] G-protein alpha (12/13):GTP [plasma membrane] [Homo sapiens]
[DefinedSet:114530] Thrombin-activated PARs [plasma membrane] [Homo sapiens]
[Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
[Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2010-09-21
reviewed[InstanceEdit:870306] Jupe, S, 2010-06-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105275] R-HSA-397891.4
summation[Summation:392198] The classical view of G-protein signalling is that the G-pro...
(hasEvent)[Pathway:456926] Thrombin signalling through proteinase activated receptors (PARs) [Homo sapiens]
(precedingEvent)[Reaction:114548] G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) [Homo sapiens]
[Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens]
[Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens]
[Reaction:398184] LARG activation by G alpha 12/13 [Homo sapiens]
[Reaction:418574] G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens]
[Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens]
[Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens]
[Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens]
[Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens]
[Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens]
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