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Details on Person The classic signalling route for G alpha (q) is activation o...
| Class:Id | Summation:397840 |
|---|---|
| _displayName | The classic signalling route for G alpha (q) is activation o... |
| _timestamp | 2017-07-10 12:30:46 |
| created | [InstanceEdit:397839] Jupe, S, 2009-03-13 14:50:53 |
| literatureReference | [LiteratureReference:397801] Protease-activated receptors in hemostasis, thrombosis and vascular biology [LiteratureReference:398166] Defective platelet activation in G alpha(q)-deficient mice [LiteratureReference:8964338] Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase [LiteratureReference:8949498] Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits |
| modified | [InstanceEdit:398167] Jupe, S, 2009-03-18 10:24:25 [InstanceEdit:416478] Jupe, S, 2009-03-27 13:03:58 [InstanceEdit:434710] Jupe, S, 2009-09-02 [InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10 |
| text | The classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides a path to calcium-regulated kinases and phosphatases, GEFs, MAP kinase cassettes and other proteins that mediate cellular responses ranging from granule secretion, integrin activation, and aggregation in platelets. Gq participates in many other signalling events including direct interaction with RhoGEFs that stimulate RhoA activity and inhibition of PI3K. Both in vitro and in vivo, the G-protein Gq seems to be the predominant mediator of the activation of platelets. Moreover, G alpha (q) can stimulate the activation of Burton tyrosine kinase (Ma Y C et al. 1998). Regulator of G-protein Signalling (RGS) proteins can regulate the activity of G alpha (z) (Soundararajan M et al. 2008). |
| (summation) | [Pathway:416476] G alpha (q) signalling events [Homo sapiens] |
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