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Details on Person Thrombin-activated PARs:Gq (active) dissociate

Class:Id	Reaction:397835
_displayName	Thrombin-activated PARs:Gq (active) dissociate
_doRelease	TRUE
_timestamp	2020-12-02 14:23:40
authored	[InstanceEdit:435013] Akkerman, JW, 2009-09-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:397834] Jupe, S, 2009-03-13 14:31:31
edited	[InstanceEdit:870306] Jupe, S, 2010-06-07
input	[Complex:397802] Thrombin-activated PAR:Gq (active) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:397886] Jupe, S, 2009-03-13 15:51:41 [InstanceEdit:398204] D'Eustachio, P, 2009-03-18 14:20:40 [InstanceEdit:400660] Jupe, S, 2009-03-24 17:26:12 [InstanceEdit:416495] Jupe, S, 2009-03-27 14:27:22 [InstanceEdit:421609] Jupe, S, 2009-05-19 09:41:31 [InstanceEdit:428743] Jupe, S, 2009-07-08 [InstanceEdit:870420] Jupe, S, 2010-06-08 [InstanceEdit:8981176] Duenas, Corina, 2017-03-03 [InstanceEdit:9708864] Jassal, Bijay, 2020-12-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Thrombin-activated PARs:Gq (active) dissociate
output	[Complex:114534] G-protein alpha (q/11): GTP [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [DefinedSet:114530] Thrombin-activated PARs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:114558] Thrombin-activated PARs activate Gq [Homo sapiens] [Reaction:396996] Thrombin-activated PARs binds G-protein Gq [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104536] R-HSA-397835.4
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:456926] Thrombin signalling through proteinase activated receptors (PARs) [Homo sapiens]
(precedingEvent)	[Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:398188] PLC beta is activated by G alpha (q) [Homo sapiens] [Reaction:400586] G alpha (q) binds to Trio family RhoGEFs [Homo sapiens] [Reaction:416358] G alpha (q) inhibits PI3K alpha [Homo sapiens] [Reaction:416510] GRK5 sequesters activated Gq [Homo sapiens] [Reaction:416516] GRK2 sequesters activated Gq [Homo sapiens] [Reaction:418582] G alpha (q) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] List all 13 refering instances
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