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Details on Person SUMO1:PIAS4 SUMOylate TCF7L2 (TCF4) with SUMO1

Class:Id	Reaction:3968368
_displayName	SUMO1:PIAS4 SUMOylate TCF7L2 (TCF4) with SUMO1
_timestamp	2022-01-19 16:45:16
authored	[InstanceEdit:3927966] May, B, 2013-07-21
catalystActivity	[CatalystActivity:3968360] SUMO transferase activity of monoSUMO1-K35-PIAS4 [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9643437] SUMO transferase activity of SUMO1-K35-PIAS4 [nucleoplasm] SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3968393] May, B, 2013-07-23
edited	[InstanceEdit:3927966] May, B, 2013-07-21
input	[EntityWithAccessionedSequence:201923] TCF7L2 [nucleoplasm] [Homo sapiens] [Complex:2993783] SUMO1:C93-UBE2I [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3968399] SUMO-1 modification of PIASy, an E3 ligase, is necessary for PIASy-dependent activation of Tcf-4 [LiteratureReference:3968359] Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
modified	[InstanceEdit:5228528] May, B, 2014-01-13 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9762281] May, Bruce, 2022-01-19
name	SUMO1:PIAS4 SUMOylate TCF7L2 (TCF4) with SUMO1
output	[EntityWithAccessionedSequence:912481] UBE2I [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3968434] monoSUMO1-K320-TCF7L2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) [Homo sapiens] [Reaction:2990833] Conjugation of SUMO1 to UBA2:SAE1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8911380] R-HSA-3968368.1
summation	[Summation:3968389] SUMOylated PIAS4 (PIASy) SUMOylates TCF7L2 (TCF4) at lysine-...
(hasEvent)	[Pathway:3232118] SUMOylation of transcription factors [Homo sapiens]
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No pathways have been reviewed or authored by SUMO1:PIAS4 SUMOylate TCF7L2 (TCF4) with SUMO1 (3968368)