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Details on Person G-protein subunits dissociate from WNT:FZD complex

Class:Id	Reaction:3965447
_displayName	G-protein subunits dissociate from WNT:FZD complex
_doRelease	TRUE
_timestamp	2014-11-20 02:41:08
authored	[InstanceEdit:3858502] Rothfels, K, 2013-07-09
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:3965448] Rothfels, K, 2013-07-23
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
input	[Complex:3965394] WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:4539765] Frizzleds: new members of the superfamily of G-protein-coupled receptors [LiteratureReference:4546341] Wnt-frizzled signaling to G-protein-coupled effectors [LiteratureReference:508598] G protein betagamma subunits: central mediators of G protein-coupled receptor signaling [LiteratureReference:4086381] Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP
modified	[InstanceEdit:4551578] Rothfels, K, 2013-09-13 [InstanceEdit:5097273] Rothfels, K, 2013-11-11 [InstanceEdit:5099837] Rothfels, K, 2013-11-13 [InstanceEdit:5144512] Rothfels, K, 2013-11-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	G-protein subunits dissociate from WNT:FZD complex
output	[Complex:3965390] WNT5A/11:FZD [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [DefinedSet:3965383] G-protein alpha (o/t2) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3965444] WNT:FZD complex promotes G-protein nucleotide exchange [Homo sapiens] [Reaction:3965441] FZD recruits trimeric G-proteins [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644573] R-HSA-3965447.2
summation	[Summation:4551470] After nucleotide exchange, the G-protein alpha subunit disso...
(hasEvent)	[Pathway:4086398] Ca2+ pathway [Homo sapiens]
(precedingEvent)	[Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:4086393] G alpha t2 binds and activates PDE6 [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] [Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens] [NegativePrecedingEvent:9864363] Futile Cycle: G-protein subunits dissociate from WNT:FZD complex
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