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Details on Person FZD recruits trimeric G-proteins

Class:Id	Reaction:3965441
_displayName	FZD recruits trimeric G-proteins
_doRelease	TRUE
_timestamp	2024-03-07 02:53:22
authored	[InstanceEdit:3858502] Rothfels, K, 2013-07-09
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:3965442] Rothfels, K, 2013-07-23
edited	[InstanceEdit:4663813] Matthews, L, 2013-10-07
inferredFrom	[Reaction:4551534] RFzd binds trimeric G-proteins [Mus musculus]
input	[Complex:3965390] WNT5A/11:FZD [plasma membrane] [Homo sapiens] [Complex:3965398] Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:3965291] Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat [LiteratureReference:517384] Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling [LiteratureReference:4539763] Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation [LiteratureReference:1498697] Proximal events in Wnt signal transduction [LiteratureReference:4546339] Wnt signaling and heterotrimeric G-proteins: strange bedfellows or a classic romance?
modified	[InstanceEdit:4551575] Rothfels, K, 2013-09-13 [InstanceEdit:5097271] Rothfels, K, 2013-11-11 [InstanceEdit:5144516] Rothfels, K, 2013-11-15 [InstanceEdit:6792888] Rothfels, Karen, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9864381] Orlic-Milacic, Marija, 2024-03-07
name	FZD recruits trimeric G-proteins
negativePrecedingEvent	[NegativePrecedingEvent:9864363] Futile Cycle: G-protein subunits dissociate from WNT:FZD complex
output	[Complex:3965393] WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3965446] WNT5A and WNT11 bind FZD receptors to initiate Ca2+ signaling [Homo sapiens] [Reaction:3247843] secretion of WNT ligands [Homo sapiens]
releaseDate	2013-12-04
reviewed	[InstanceEdit:5099870] Kikuchi, Akira, 2013-11-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644608] R-HSA-3965441.4
summation	[Summation:4551562] Studies with FZD receptors in zebrafish, Xenopus and mouse t...
(hasEvent)	[Pathway:4086398] Ca2+ pathway [Homo sapiens]
(precedingEvent)	[Reaction:3965444] WNT:FZD complex promotes G-protein nucleotide exchange [Homo sapiens]
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No pathways have been reviewed or authored by FZD recruits trimeric G-proteins (3965441)