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Details on Person UniProt:Q3V0K9 Pls1
| Class:Id | ReferenceGeneProduct:395072 |
|---|---|
| _chainChangeLog | chain:1-630 added on Fri February 6 2015 |
| _displayName | UniProt:Q3V0K9 Pls1 |
| _timestamp | 2023-11-03 16:25:12 |
| chain | chain:1-630 |
| checksum | 1F7254CB97780742 |
| comment | FUNCTION Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions (PubMed:27811163).SUBUNIT Monomer.SUBCELLULAR LOCATION In the inner ear, it is expressed in the organ of Corti (PubMed:25124451). Abundant in the utricle (at protein level) (PubMed:27811163).PTM Phosphorylated.DISRUPTION PHENOTYPE Knockout animals have a progressive form of hearing loss at all frequencies. Hearing loss is moderate in young adult mice, progresses to severe deafness with age, and is associated with defects in stereocilia morphology. Stereocilia are shorter and narrower than those of wild-type mice. |
| created | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 |
| description | recommendedName: Plastin-1 |
| geneName | Pls1 |
| identifier | Q3V0K9 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Actin-binding Calcium Cell projection Cytoplasm Metal-binding Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Pls1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PLSI_MOUSE |
| sequenceLength | 630 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9662396] Pls1 [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q3V0K9 Pls1 (395072)
