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Details on Person UniProt:Q9DDT2 PIK3AP1
| Class:Id | ReferenceGeneProduct:394872 |
|---|---|
| _chainChangeLog | chain:1-800 added on Fri February 6 2015 |
| _displayName | UniProt:Q9DDT2 PIK3AP1 |
| _timestamp | 2023-11-03 16:18:40 |
| chain | chain:1-800 |
| checksum | E506D0CFE5E558ED |
| comment | FUNCTION Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.SUBUNIT Homooligomer (By similarity). Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase.SUBCELLULAR LOCATION The DBB domain is required for dimerization.PTM Constitutively phosphorylated (By similarity). Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation.MISCELLANEOUS It is unsure whether this isoform is produced by alternative splicing or alternative initiation. |
| created | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 |
| description | recommendedName: Phosphoinositide 3-kinase adapter protein 1 alternativeName: B-cell adapter for phosphoinositide 3-kinase alternativeName: B-cell phosphoinositide 3-kinase adapter protein 1 |
| geneName | PIK3AP1 BCAP |
| identifier | Q9DDT2 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Coiled coil Cytoplasm Direct protein sequencing Membrane Phosphoprotein Reference proteome |
| modified | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | PIK3AP1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | BCAP_CHICK Q9DDL3 |
| sequenceLength | 800 |
| species | [Species:49591] Gallus gallus |
| (isoformParent) | [ReferenceIsoform:394873] UniProt:Q9DDT2-2 PIK3AP1 [Gallus gallus] [ReferenceIsoform:413986] UniProt:Q9DDT2-1 PIK3AP1 [Gallus gallus] |
| (referenceEntity) | [EntityWithAccessionedSequence:984815] p-Y266,Y423,Y448,Y463-PIK3AP1 [plasma membrane] [Gallus gallus] |
| (referenceSequence) | [ModifiedResidue:984800] O4'-phospho-L-tyrosine at 463 [ModifiedResidue:984809] O4'-phospho-L-tyrosine at 423 [ModifiedResidue:984810] O4'-phospho-L-tyrosine at 448 [ModifiedResidue:984812] O4'-phospho-L-tyrosine at 266 |
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No pathways have been reviewed or authored by UniProt:Q9DDT2 PIK3AP1 (394872)
