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Details on Person UniProt:P79996 MAPK9
| Class:Id | ReferenceGeneProduct:394028 |
|---|---|
| _chainChangeLog | chain:1-382 added on Fri February 6 2015 |
| _displayName | UniProt:P79996 MAPK9 |
| _timestamp | 2025-02-21 19:40:09 |
| chain | chain:1-382 |
| checksum | 9A737C925465E54C |
| comment | FUNCTION Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Activated by threonine and tyrosine phosphorylation.TISSUE SPECIFICITY Expressed in the neuroepithelium of developing brain at stages 16 to 26.DOMAIN The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. |
| created | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 |
| description | recommendedName: Mitogen-activated protein kinase 9 shortName: MAP kinase 9 shortName: MAPK 9 ecNumber: 2.7.11.24 alternativeName: Stress-activated protein kinase JNK2 alternativeName: c-Jun N-terminal kinase 2 |
| geneName | MAPK9 JNK2 |
| identifier | P79996 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Biological rhythms Kinase Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase |
| modified | [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MAPK9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MK09_CHICK |
| sequenceLength | 382 |
| species | [Species:49591] Gallus gallus |
| (referenceEntity) | [EntityWithAccessionedSequence:434057] MAPK9_(JNK2) [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:437993] phosphorylated MAPK9_(JNK2) [nucleoplasm] [Gallus gallus] [EntityWithAccessionedSequence:438015] phosphorylated MAPK9_(JNK2) [cytosol] [Gallus gallus] [EntityWithAccessionedSequence:446234] MAPK9_(JNK2) [nucleoplasm] [Gallus gallus] |
| (referenceSequence) | [ModifiedResidue:438017] O4'-phospho-L-tyrosine at 185 [ModifiedResidue:438018] O-phospho-L-threonine at 183 |
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No pathways have been reviewed or authored by UniProt:P79996 MAPK9 (394028)
