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IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE.
WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE
Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
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Details on Person UniProt:Q90615 ITGA1
Class:Id
ReferenceGeneProduct:394021
_chainChangeLog
chain:- added on Sat February 7 2015
_displayName
UniProt:Q90615 ITGA1
_timestamp
2023-11-03 16:03:53
chain
chain:1-285
checksum
1B05D3246CD5CA7E
comment
FUNCTION Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity).SUBUNIT Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1.SUBCELLULAR LOCATION The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.SIMILARITY Belongs to the integrin alpha chain family.
