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Details on Person UniProt:Q90643 IRF3
Class:Id
ReferenceGeneProduct:394020
_chainChangeLog
chain:1-491 added on Fri February 6 2015
_displayName
UniProt:Q90643 IRF3
_timestamp
2023-11-03 16:22:31
chain
chain:1-491
checksum
CAE0C2AA8BE976D9
comment
FUNCTION Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.SUBCELLULAR LOCATION Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.TISSUE SPECIFICITY Widely expressed with higher expression in lung, spleen and intestine.INDUCTION Up-regulated by poly I:C.SIMILARITY Belongs to the IRF family.
