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Details on Person Dissociation of the Prostacyclin receptor:Gs complex

Class:Id	Reaction:392874
_displayName	Dissociation of the Prostacyclin receptor:Gs complex
_doRelease	TRUE
_timestamp	2010-12-02 14:41:36
authored	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:392873] Jupe, S, 2009-03-09 15:08:41
edited	[InstanceEdit:870305] Jupe, S, 2010-06-07
inferredFrom	[Reaction:421961] Dissociation of beta-2 adrenergic receptor:Gs complex [Oryctolagus cuniculus]
input	[Complex:392865] Prostacyclin:prostacyclin receptor:G-protein Gs (active) [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:421962] Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes [LiteratureReference:427945] Dissociation of heterotrimeric g proteins in cells
modified	[InstanceEdit:392880] Jupe, S, 2009-03-09 15:30:49 [InstanceEdit:418606] Jupe, S, 2009-04-24 10:40:08 [InstanceEdit:421966] Jupe, S, 2009-05-22 15:45:58 [InstanceEdit:427946] Jupe, S, 2009-06-30 [InstanceEdit:435204] Jupe, S, 2009-09-07 [InstanceEdit:870306] Jupe, S, 2010-06-07 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of the Prostacyclin receptor:Gs complex
output	[Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens] [SimpleEntity:391926] PGI2 [extracellular region] [EntityWithAccessionedSequence:391834] PTGIR [plasma membrane] [Homo sapiens] [Complex:164358] G alpha (s):GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:392870] Gs activation by prostacyclin receptor [Homo sapiens] [Reaction:392852] Activated prostacyclin receptor binds G-protein Gs [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:870290] Kunapuli, SP, 2010-06-07
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105849] R-HSA-392874.2
summation	[Summation:392198] The classical view of G-protein signalling is that the G-pro...
(hasEvent)	[Pathway:392851] Prostacyclin signalling through prostacyclin receptor [Homo sapiens]
(precedingEvent)	[Reaction:163617] G alpha (s) activates adenylate cyclase [Homo sapiens] [Reaction:164381] G alpha (s) auto-inactivates by hydrolysing GTP to GDP [Homo sapiens] [Reaction:392295] Gbeta:gamma recruits PI3K gamma [Homo sapiens] [Reaction:398040] Gbeta:gamma activation of PLC beta [Homo sapiens] [Reaction:8964156] GNB1:GNG2 binds ARHGEF18 [Homo sapiens] [Reaction:8964241] G beta-gamma complex and PIP3 recruit BTK to membrane [Homo sapiens] [Reaction:8964302] G-protein beta-gamma complex binds to ITK [Homo sapiens] [Reaction:8964605] PAK1:ARHGEF6 complex binds G-protein beta-gamma complex [Homo sapiens] [Reaction:8978882] G-protein beta-gamma complex binds to voltage-gated calcium channel [Homo sapiens]
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