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Details on Person VAV exchanges GTP for GDP on RAC1, activating it

Class:Id	Reaction:3928628
_displayName	VAV exchanges GTP for GDP on RAC1, activating it
_doRelease	TRUE
_timestamp	2017-11-07 13:46:02
authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity	[CatalystActivity:3928590] guanyl-nucleotide exchange factor activity of EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643343] guanyl-nucleotide exchange factor activity of EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] Vav family GEFs link activated Ephs to endocytosis and axon guidance
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
input	[SimpleEntity:29438] GTP [cytosol] [Complex:445010] RAC1:GDP [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3928145] Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
modified	[InstanceEdit:4093328] Garapati, P V, 2013-08-14 [InstanceEdit:4640897] Garapati, P V, 2013-09-27 [InstanceEdit:5096527] Garapati, P V, 2013-11-11 [InstanceEdit:5096559] Garapati, P V, 2013-11-11 [InstanceEdit:5097236] Garapati, P V, 2013-11-11 [InstanceEdit:5099816] Garapati, P V, 2013-11-12 [InstanceEdit:5144541] Garapati, P V, 2013-11-18 [InstanceEdit:5490336] Garapati, P V, 2014-05-19 [InstanceEdit:9028364] Orlic-Milacic, Marija, 2017-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VAV exchanges GTP for GDP on RAC1, activating it
output	[SimpleEntity:29420] GDP [cytosol] [Complex:442641] RAC1:GTP [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3928604] SFKs phosphorylate VAV2,3 [Homo sapiens] [Reaction:3928607] p-EPHs bind VAV2,3 [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644686] R-HSA-3928628.4
summation	[Summation:3814788] Activated proto-oncogene vav (VAV) act as guanine nucleotide...
(hasEvent)	[Pathway:3928665] EPH-ephrin mediated repulsion of cells [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780180] Update Tracker - [Reaction:3928628] VAV exchanges GTP for GDP on RAC1, activating it - v63:[add_removeOutput, removeInput] [_UpdateTracker:9846653] Update Tracker - [Reaction:3928628] VAV exchanges GTP for GDP on RAC1, activating it - v84:[modifyText]
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