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Details on Person EPHB phosphorylates TIAM1

Class:Id	Reaction:3928627
_displayName	EPHB phosphorylates TIAM1
_doRelease	TRUE
_timestamp	2014-11-20 02:36:51
authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity	[CatalystActivity:3928637] protein tyrosine kinase activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643636] protein tyrosine kinase activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
input	[SimpleEntity:113592] ATP [cytosol] [Complex:3928541] EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3928164] The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development
modified	[InstanceEdit:4443762] Garapati, P V, 2013-09-03 [InstanceEdit:4640897] Garapati, P V, 2013-09-27 [InstanceEdit:5096527] Garapati, P V, 2013-11-11 [InstanceEdit:5096559] Garapati, P V, 2013-11-11 [InstanceEdit:5097236] Garapati, P V, 2013-11-11 [InstanceEdit:5099816] Garapati, P V, 2013-11-12 [InstanceEdit:5144541] Garapati, P V, 2013-11-18 [InstanceEdit:5490336] Garapati, P V, 2014-05-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EPHB phosphorylates TIAM1
output	[SimpleEntity:29370] ADP [cytosol] [Complex:3928518] EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3928645] EPHB:NMDAR binds TIAM1 [Homo sapiens] [Reaction:3928583] FYN phosphorylates NMDAR2B [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644412] R-HSA-3928627.3
summation	[Summation:3928282] Once recruited to the EPHB:NMDAR complex, T-lymphoma invasio...
(hasEvent)	[Pathway:3928662] EPHB-mediated forward signaling [Homo sapiens]
(precedingEvent)	[Reaction:4093336] p-TIAM1 exchanges GTP for GDP on RAC1, activating it [Homo sapiens]
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No pathways have been reviewed or authored by EPHB phosphorylates TIAM1 (3928627)