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Details on Person SFKs phosphorylate VAV2,3

Class:Id	Reaction:3928604
_displayName	SFKs phosphorylate VAV2,3
_doRelease	TRUE
_timestamp	2014-11-20 02:42:14
authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity	[CatalystActivity:3928618] protein tyrosine kinase activity of EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643501] protein tyrosine kinase activity of EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] Vav2 is required for cell spreading
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
input	[Complex:3928540] EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:3928129] Vav family GEFs link activated Ephs to endocytosis and axon guidance [LiteratureReference:3928143] Vav2 is required for cell spreading
modified	[InstanceEdit:4093328] Garapati, P V, 2013-08-14 [InstanceEdit:4640897] Garapati, P V, 2013-09-27 [InstanceEdit:5096527] Garapati, P V, 2013-11-11 [InstanceEdit:5096559] Garapati, P V, 2013-11-11 [InstanceEdit:5097236] Garapati, P V, 2013-11-11 [InstanceEdit:5099816] Garapati, P V, 2013-11-12 [InstanceEdit:5144541] Garapati, P V, 2013-11-18 [InstanceEdit:5490336] Garapati, P V, 2014-05-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SFKs phosphorylate VAV2,3
output	[Complex:3928532] EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:3928607] p-EPHs bind VAV2,3 [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644617] R-HSA-3928604.3
summation	[Summation:3928300] Upon ephrin (EFN)-mediated stimulation, proto-oncogene vav (...
(hasEvent)	[Pathway:3928665] EPH-ephrin mediated repulsion of cells [Homo sapiens]
(precedingEvent)	[Reaction:3928628] VAV exchanges GTP for GDP on RAC1, activating it [Homo sapiens]
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No pathways have been reviewed or authored by SFKs phosphorylate VAV2,3 (3928604)