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Details on Person Ptk2 autophosphorylates at Y397
Class:Id Reaction:3928599
_displayName Ptk2 autophosphorylates at Y397
_doRelease TRUE
_timestamp 2017-07-12 18:14:56
authored [InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity [CatalystActivity:3928587] protein tyrosine kinase activity of ephrin-B2:Ephb2:FAK1 [plasma membrane]
catalystActivityReference [CatalystActivityReference:9644012] protein tyrosine kinase activity of ephrin-B2:Ephb2:FAK1 [plasma membrane] EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol
created [InstanceEdit:3928638] Garapati, P V, 2013-07-22
edited [InstanceEdit:3928653] Garapati, P V, 2013-07-22
entityOnOtherCell [EntityWithAccessionedSequence:3928450] Ephrin-B2 [plasma membrane] [Mus musculus]
input [SimpleEntity:113592] ATP [cytosol] [Complex:3928557] ephrin-B2:Ephb2:FAK1 [plasma membrane] [Mus musculus]
isChimeric FALSE
literatureReference [LiteratureReference:3928042] Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity [LiteratureReference:3928044] EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation [LiteratureReference:372615] Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src
modified [InstanceEdit:4640897] Garapati, P V, 2013-09-27 [InstanceEdit:5096527] Garapati, P V, 2013-11-11 [InstanceEdit:5096559] Garapati, P V, 2013-11-11 [InstanceEdit:5097236] Garapati, P V, 2013-11-11 [InstanceEdit:5099816] Garapati, P V, 2013-11-12 [InstanceEdit:5144541] Garapati, P V, 2013-11-18 [InstanceEdit:5490336] Garapati, P V, 2014-05-19 [InstanceEdit:9012335] D'Eustachio, Peter, 2017-07-12 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name Ptk2 autophosphorylates at Y397
output [SimpleEntity:29370] ADP [cytosol] [Complex:3928508] ephrin-B2:Ephb2:p-Y428-FAK1 [plasma membrane] [Mus musculus]
releaseDate 2014-06-10
reviewed [InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus [ReviewStatus:9821382] five stars
species [Species:48892] Mus musculus
stableIdentifier [StableIdentifier:5644727] R-MMU-3928599.4
summation [Summation:3928290] Focal adhesion kinase 1 (PTK2, FAK, FAK1) activation plays a...
(inferredFrom) [Reaction:3928610] PTK2 autophosphorylates at Y397 [Homo sapiens]
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