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Details on Person Recruitment of p190RhoGEF to p-FAK

Class:Id	Reaction:3928598
_displayName	Recruitment of p190RhoGEF to p-FAK
_doRelease	TRUE
_timestamp	2014-11-20 02:55:47
authored	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3928638] Garapati, P V, 2013-07-22
edited	[InstanceEdit:3928653] Garapati, P V, 2013-07-22
input	[Complex:3928549] EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:3928474] ARHGEF28 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3928214] Direct interaction of focal adhesion kinase with p190RhoGEF [LiteratureReference:3928044] EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation [LiteratureReference:3927979] Control of axonal branching and synapse formation by focal adhesion kinase
modified	[InstanceEdit:4443762] Garapati, P V, 2013-09-03 [InstanceEdit:5096527] Garapati, P V, 2013-11-11 [InstanceEdit:5096559] Garapati, P V, 2013-11-11 [InstanceEdit:5097236] Garapati, P V, 2013-11-11 [InstanceEdit:5099816] Garapati, P V, 2013-11-12 [InstanceEdit:5144541] Garapati, P V, 2013-11-18 [InstanceEdit:5490336] Garapati, P V, 2014-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of p190RhoGEF to p-FAK
output	[Complex:3928563] EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:3928610] PTK2 autophosphorylates at Y397 [Homo sapiens] [Reaction:3928588] EPHBs binds PTK2 [Homo sapiens]
releaseDate	2014-06-10
reviewed	[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5645130] R-HSA-3928598.2
summation	[Summation:3928317] FAK-mediated spine morphogenesis was shown to occur, in part...
(hasEvent)	[Pathway:3928662] EPHB-mediated forward signaling [Homo sapiens]
(precedingEvent)	[Reaction:3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it [Homo sapiens]
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No pathways have been reviewed or authored by Recruitment of p190RhoGEF to p-FAK (3928598)