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Details on Person ROCK phosphorylates LIMK1,2

Class:IdReaction:3928577
_displayNameROCK phosphorylates LIMK1,2
_doReleaseTRUE
_timestamp2014-11-20 02:43:41
authored[InstanceEdit:3928653] Garapati, P V, 2013-07-22
catalystActivity[CatalystActivity:3928585] protein serine/threonine kinase activity of RHOA:GTP:ROCK1,ROCK2 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9644011] protein serine/threonine kinase activity of RHOA:GTP:ROCK1,ROCK2 [plasma membrane] Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:3928638] Garapati, P V, 2013-07-22
edited[InstanceEdit:3928653] Garapati, P V, 2013-07-22
inferredFrom
input[CandidateSet:419708] LIM Kinases [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
modified[InstanceEdit:4443762] Garapati, P V, 2013-09-03
[InstanceEdit:4640897] Garapati, P V, 2013-09-27
[InstanceEdit:5096527] Garapati, P V, 2013-11-11
[InstanceEdit:5096559] Garapati, P V, 2013-11-11
[InstanceEdit:5097236] Garapati, P V, 2013-11-11
[InstanceEdit:5099816] Garapati, P V, 2013-11-12
[InstanceEdit:5144541] Garapati, P V, 2013-11-18
[InstanceEdit:5490336] Garapati, P V, 2014-05-19
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameROCK phosphorylates LIMK1,2
output[CandidateSet:419709] p-LIMK [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2014-06-10
reviewed[InstanceEdit:5490284] Ip, Nancy Y, 2014-05-19
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644669] R-HSA-3928577.3
summation[Summation:3928308] Rho-associated kinases (ROCKs) contribute to the formation o...
(hasEvent)[Pathway:3928662] EPHB-mediated forward signaling [Homo sapiens]
(precedingEvent)[Reaction:3928608] LIMK phosphorylates CFL1, inactivating it [Homo sapiens]
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No pathways have been reviewed or authored by ROCK phosphorylates LIMK1,2 (3928577)